Why the Maternal Medication List Matters: Neonatal Toxicity From Combined Serotonergic Exposures

نویسندگان

چکیده

Serotonergic medications are used for the prevention and treatment of depression during pregnancy. Selective serotonin reuptake inhibitors serotonin-norepinephrine (SNRIs) can cause poor neonatal adaptation, which has been attributed to withdrawal versus toxicity. Bupropion, a norepinephrine-dopamine inhibitor, is often as an adjunctive agent selective or SNRIs refractory depression. Quetiapine, atypical antipsychotic, may also be in more complex cases. When combined with serotonergic drugs, bupropion quetiapine associated increased risk syndrome adults. We describe neonate exposed venlafaxine (an SNRI), bupropion, utero who presented nearly immediately after birth encephalopathy abnormal movements. The severity rapidity symptoms attributable potentiation venlafaxine’s effects by quetiapine. Neonatal providers should aware maternal prepare possible adverse effects, particularly from common psychotropic exposures.

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2021

ISSN: ['1098-4275', '0031-4005']

DOI: https://doi.org/10.1542/peds.2019-2250